General Cell Lines and Cell Cultures
ACROBiosystems CHO/Human CD79B Stable Cell Line Development Service
B-cell antigen receptor complex-associated protein beta chain (CD79b) is also known as B-cell-specific glycoprotein B29, Ig-beta,Immunoglobulin-associated B29 protein, B29 and IGB, which is a single-pass type I membrane protein containing one Ig-like V-type ( immunoglobulin-like ) domain and one ITAM domain.CD79b is required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR).CD79b can enhance phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. Defects in CD79b are the cause of agammaglobulinemia type 6 (AGM6) that is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of B-cell development.
ACROBiosystems CHO/Human PD-L1 Stable Cell Line (Low Expression) Development Service
Programmed cell death 1 ligand 1 (PDL1) is also known as B7-H, B7H1, MGC142294, MGC142296, PD-L1, PDCD1L1 and PDCD1LG1,which is a member of the growing B7 family of immune molecules and is involved in the regulation of cellular and humoral immune responses.PDL1 is a cell surface immunoglobulin superfamily with two Ig-like domains within the extracellular region and a short cytoplasmic domain. This protein is broadly expressed in the majority of peripheral tissues as well as hematopoietic cells. Interaction between PDL1 and its receptors belonging to the CD28 family of molecules provide both stimulatory and inhibitory signals in regulating T cell activation and tolerance. PDL1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression.
Medchemexpress LLC CD47 protein, rat (HEK293, His-tag) | >95.0% | 500 UG
Recombinant rat CD47 extracellular domain produced in HEK293 cells, purified with a C-terminal His tag and supplied lyophilized for research applications such as binding studies, functional assays, and antibody generation. Reconstitute and aliquot per manufacturer recommendations prior to use.
- Rat CD47 extracellular domain (Q19-K140).
- C-terminal His tag for affinity purification.
- Apparent molecular weight ~23-40 kDa due to glycosylation.
- Purity greater than 95% by reducing SDS-PAGE.
- Lyophilized formulation from PBS, pH 7.4.
- Store at -20°C; freeze aliquots at -20°C or -80°C for extended storage.
- Suitable for biochemical assays, binding studies, and antibody generation.
ATCC Mycoplasma pneumoniae; Strain FH
Mycoplasma pneumoniae FH strain of Eaton Agent [NCTC 10119] is the first Mycoplasma known to be the etiological agent of a human disease. The strain was isolated by Hayflick from monkey kidney tissue-culture fluids of the FH strain (Eaton Agent Virus) supplied by C. Liu, who recovered this strain in embryonated eggs from a student with atypical pneumonia. This bacterium is provided with titer data (CFU) and calculated genome copy numbers, making it useful for assay development and quality control.
Biochain Institute Inc Paraffin Tissue Section - Human Brain Tumor: Meningioma (Necrotic), 5 sides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's formalin fixed paraffin embedded (FFPE) tissue section line encompasses a large selection of tissue sections which are suitable for immunohistochemistry and in situ hybridization assays. The tissue sections are approximately 5 um thick. Each slide contains tissue from a single human tumor. Documentation of tissues' clinical histories may be available upon request. For those customers who want to perform FFPE DNA and RNA isolation, BioChain can provide tissue section slices in tubes instead of mounting them on glass slides.
Eurofins Discoverx PathHunter CHO-K1 TACR1 β-Arrestin Cell Line, 2 vials. (93-0344C2)
The PathHunter TACR1 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. substance P) based activation of TACR1 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged TACR1 and EA-tagged β-Arrestin-2. Activation of TACR1 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Cayman Chemical ApelIn-12humnmouserat10mg
An endogenous agonist of the APJ receptor; induces calcium mobilization in APJ-Gαq16 cells expressing human APJ (EC50 = 0.18 nM); inhibits HIV-1 and HIV-2 infection in NP-2/CD4/APJ cells (mean IC50 = 63 UG/ml); inhibits or stimulates the expression of genes associated with apoptosis, mitosis, and DNA repair in IEC-6 and Caco-2 cells, respectively, at 0.01 µM; induces the production of NO in HUVECs from 100-1,000 nM; increases gastric acid secretion, as well as stomach histamine synthesis and secretion in rats from 20-100 UG/kg; reduces MAP in rats at 15 UG/kg
Eurofins Discoverx RBL-2H3 ADORA2A Gq Cell Line, 2 vials. (95-1008C11)
The ADORA2A Gq cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. adenosine, NECA) based activation of ADORA2A GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses ADORA2A, a naturally Gq coupled GPCR. Upon activation of ADORA2A, the resulting calcium activity can be fluorescently assayed using the Calcium No WashPLUS Detection Kit. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Amsbio LLC TCF/LEF Leeporter™ Luciferase Reporter-HEK293 Cell Line
TCF/LEF Leeporter™ Luciferase Reporter-HEK293 Cell Line
Biochain Institute Inc Frozen Tissue Section - Human Diabetic Diseased Tissue: Small Intestine: Duodenum, 5 slides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's Frozen Tissue Slides are ideal for rapidly identifying cellular localization of RNA or protein. A single human adult normal tissue with 5-10 um thickness is mounted on a positively charged glass slide. The slides are fixed and dehydrated with acetone for consistent results with in situ hybridization and immunohistochemistry. More organs may be available upon request.
Eurofins Discoverx PrecisION hTRPV1 Recombinant Stable Cell Line, 2 vials. (CYL3063)
The PrecisION hTRPV1 Recombinant Stable Cell Line is a stable, engineered cell line for use in studying TRPV1 ion channels, including drug candidates which affect channel function. This cell line enables assessment of ion channel function via detection of electrophysiological signals. The included cell line overexpresses TRPV1 ion channels. Upon ligand/agonist induced channel activation, response can be detected via automated or manual electrophysiological techniques. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/ion-channels.
ATCC Hs 822.T; Ewing's Sarcoma; Human (Homo sapiens)
There is a Permit requirement: License form needed to be completed Material Transfer Agreement Addendum for Screening Application
The forms are available here: https://www.atcc.org/support/order-support/permits-and-restrictions
ATCC Quantitative Genomic DNA from; Human adenovirus 2; Strain: Adenoid 6
Quantitative genomic DNA from Human adenovirus 2 strain Adenoid 6 can be used for assay development, verification, and validation as well as monitoring of day to day test variation and lot to lot performance of molecular-based assays. The quantitative format allows for the generation of a standard curve for quantitative PCR (qPCR) to determine viral load.